The White Bone Spirit is a spiritual demon and an enemy of the Monkey King. After being sealed, she prepares her revenge against her old enemy. After the Demon Bull King freed her, she possessed him and used him to take over the city until MK freed the Demon Bull King from the White Bone Spirit's possession.
After some of the Bull Clones fully uncover tomb, D.B.K. tries to get it open himself. However, Princess Iron Fan tells her husband that none of them have the power to open it, and that they would need an object of equal strength. Red Son says they need a key to open it, and he found it at Pigsy's Noodles. Later, after Red Son obtained the key, the tomb is opened. After being freed from her tomb, the White Bone Spirit took possession of the Demon Bull King and the Bull Clones.
After the Demon Bull King mocks Red Son, the White Bone Spirit tells the Demon Bull King that Red Son is a traitor so the he can turn against him. However, when Princess Iron Fan blocks the Demon Bull King's punch when he attempted to punch Red Son, the White Bone Spirit also calls her a traitor so the Demon Bull King can kill her as well.
Once MK entered the Flaming Foundry, the White Bone Spirit uses the Demon Bull King to kill MK as well. Although, when the White Bone Spirit was tricked into destroying an MK Clone instead of the real one, MK was able to destroy the canisters from the Demon Bull King's armor, freeing the Demon Bull King and the Bull Clones from the White Bone Spirit's possession.
Unbeknownst to MK's Team nor the Demon Bull Family, the White Bone Spirit roamed the city until she finds a little girl and possesses her.